A man was found fatally stabbed at the Elot Junction outside the southern resort city of Eilat early Sunday morning, Israel Police said in a statement.
Emergency medical services who attended the man, 21, said he had been stabbed in the neck, according to police. He was declared dead at the scene.
Magen David Adom paramedics reported they found the man in a car, with multiple stab wounds and with no vital signs.
Police forensic teams were combing the area for evidence and a murder investigation was opened, police said.
The homicide came came amid a particularly deadly weekend of violence.
On Saturday, two men were shot dead in the central cities of Qalansawe and Jaljulia.
They were the 101st and 102nd members of the Arab community to have been killed so far this year, in a spiraling crime wave that has claimed the lives of ten people just over the past three days.
Their deaths came hours after a 21-year-old resident of a Bedouin community in the Negev desert was stabbed to death during a scuffle with foreign workers near the southern city of Ofakim. Police said it appeared the victim was part of a group attempting to steal agricultural equipment.
On Friday, an 18-year-old woman was shot dead in northern Israel; and on Thursday, five people were killed in the northern Arab town of Yafa an-Naseriyye, in one of the worst single acts of criminal violence in recent years.
Critics and protesters have pointed the finger at Prime Minister Benjamin Netanyahu, whose government was sworn in on December 29, 2022, as well as far-right National Security Minister Itamar Ben Gvir, on whom half a dozen former police chiefs called to step aside on Friday as the rampant bloodshed continues.